In a large pot, bring salted water to a boil and cook the elbow macaroni according to package instructions until al dente. Drain and set aside.
In a large skillet, heat olive oil over medium heat. Add the ground turkey and cook until browned, breaking it up into crumbles, about 5-7 minutes. Season with garlic powder, onion powder, salt, and pepper.
Stir in the cream of chicken soup, ranch dressing, milk, and frozen mixed vegetables into the skillet. Mix well and cook for another 5 minutes until everything is heated through.
Add the cooked macaroni and half of the shredded cheddar cheese into the skillet, mixing until all ingredients are combined.
Transfer the mixture to a greased 9x13 inch baking dish. Top with the remaining cheddar cheese and sprinkle breadcrumbs on top if desired for added crunch.
Bake in the preheated oven for 25-30 minutes, or until the cheese is bubbly and golden.
Notes
Serve directly from the baking dish and garnish with chopped fresh parsley for a pop of color!